Staging

Staging CLL

Rai Staging
The Rai staging system is more commonly used in North America. There is another staging system called Binet staging that is used in Europe. Both classify CLL and assign risk categories based on:

  • Number of lymphocytes found in the blood
  • Enlargement of the lymph nodes, liver and spleen
  • Number of platelets found in the blood
  • Presence of anemia (low number of red blood cells in the blood).

Risk Level

 Rai Stage

 Symptoms

 Binet Equivalent

Low

 0

  • Too many lymphocytes in the blood
  • No other symptoms

 A

Intermediate 

 1

  • Too many lymphocytes in the blood
  • Lymph nodes are larger than normal

 B

 2

  • Too many lymphocytes in the blood
  • Lymph nodes may be larger than normal
  • Spleen or liver are larger than normal

High 

 3

  • Too many lymphocytes in the blood
  • Low red blood cells in the blood (anemia)
  • Spleen, liver or lymph nodes may be larger than normal

 C

 4

  • Too many lymphocytes in the blood
  • Low red blood cells in the blood (anemia)
  • Low platelets in the blood (thrombocytopenia)
  • Spleen, liver or lymph nodes may be larger than normal