{"id":908,"date":"2019-09-11T20:21:55","date_gmt":"2019-09-11T20:21:55","guid":{"rendered":"https:\/\/www.lymphoma.ca\/?page_id=908"},"modified":"2020-02-06T03:05:38","modified_gmt":"2020-02-06T03:05:38","slug":"tests-moleculaires","status":"publish","type":"page","link":"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/","title":{"rendered":"Tests mol\u00e9culaires"},"content":{"rendered":"

 <\/p>\n

\"\u00caTES-VOUS<\/a><\/p>\n

Le m\u00e9decin peut faire passer d\u2019autres examens pour d\u00e9couvrir quelles sont les anomalies chromosomiques et les modifications g\u00e9n\u00e9tiques pr\u00e9sentes dans les cellules de la LLC. Les r\u00e9sultats de ces tests peuvent aider le m\u00e9decin \u00e0 d\u00e9cider du meilleur traitement possible. Ces tests sont g\u00e9n\u00e9ralement effectu\u00e9s \u00e0 l\u2019aide d\u2019un \u00e9chantillon de sang. Toutefois, si on pr\u00e9l\u00e8ve un \u00e9chantillon de moelle osseuse, ce m\u00eame \u00e9chantillon peut aussi servir \u00e0 la r\u00e9alisation un test de g\u00e9n\u00e9tique mol\u00e9culaire.<\/p>\n

L\u2019analyse FISH (l\u2019hybridation in situ en fluorescence) sert \u00e0 trouver les anomalies de g\u00e8nes dans les cellules canc\u00e9reuses en rendant lumineuses certaines de ces anomalies (fluorescence) pour qu\u2019elles soient plus faciles \u00e0 d\u00e9tecter. Important indicateur pronostic, l\u2019analyse FISH permet aux m\u00e9decins de classer les LLC en diff\u00e9rents groupes \u00e0 risque. Les r\u00e9sultats de ce test peuvent aider \u00e0 d\u00e9terminer quel est le meilleur type de traitement contre votre cancer<\/p>\n

Le tableau ci-dessous montre les changements chromosomiques et les mutations g\u00e9n\u00e9tiques les plus souvent observ\u00e9s chez les patients atteints de LLC.<\/h3>\n\n\n\n\n\n\n\n\n\n
\n

Mutation d\u2019un chromosome ou d\u2019un g\u00e8ne<\/h3>\n<\/td>\n

\n

Fr\u00e9quence de leur survenue chez les patients atteints de LLC<\/h3>\n<\/td>\n

\n

Impact potentiel sur l\u2019\u00e9volution de l\u2019\u00e9tat du patient<\/h3>\n<\/td>\n<\/tr>\n

12+ ou trisomie 12<\/td>\n10% \u00e0 20%<\/td>\nInconnu. Probabilit\u00e9 accrue du syndrome de Richter.<\/td>\n<\/tr>\n
Del(11q)<\/td>\n5% \u00e0 20%<\/td>\nPeut donner de mauvais r\u00e9sultats, mais \u00eatre trait\u00e9 avec succ\u00e8s par chimio-immunoth\u00e9rapie.<\/td>\n<\/tr>\n
Del(13q)<\/td>\n51% \u00e0 62%<\/td>\nBons r\u00e9sultats s\u2019il s\u2019agit uniquement de changements cytog\u00e9n\u00e9tiques.<\/td>\n<\/tr>\n
Del(17p)<\/td>\n3 % \u00e0 7 % chez les patients non trait\u00e9s.<\/td>\nMauvais r\u00e9sultats par chimioimmunoth\u00e9rapie; meilleures r\u00e9ponses des patients aux traitements cibl\u00e9s.<\/td>\n<\/tr>\n
Mutation du g\u00e8ne TP53<\/td>\nLe g\u00e8ne TP53 est souvent mut\u00e9 chez les patients pr\u00e9sentant une d\u00e9l\u00e9tion 17p, mais il peut l\u2019\u00eatre \u00e9galement chez d\u2019autres patients.<\/td>\nFaible r\u00e9ponse \u00e0 la\u00a0chimio-immunoth\u00e9rapie; meilleure r\u00e9ponse aux traitements cibl\u00e9s.<\/td>\n<\/tr>\n
Statut mutationnel du g\u00e8ne IGHV<\/td>\nPlus de 40 % des patients qui ont re\u00e7u un diagnostic\u00a0de LLC ne pr\u00e9senteront aucune mutation.<\/td>\nMut\u00e9<\/span> : Bonne r\u00e9ponse \u00e0 la chimio-immunoth\u00e9rapie.<\/p>\n

Non mut\u00e9<\/span> : Faible r\u00e9ponse \u00e0 la chimio-immunoth\u00e9rapie; meilleure r\u00e9ponse aux traitements cibl\u00e9s.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

  Le m\u00e9decin peut faire passer d\u2019autres examens pour d\u00e9couvrir quelles sont les anomalies chromosomiques et les modifications g\u00e9n\u00e9tiques pr\u00e9sentes dans les cellules de la LLC. Les r\u00e9sultats de ces…<\/p>\n","protected":false},"author":6,"featured_media":904,"parent":6279,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"page-sidebar.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-908","page","type-page","status-publish","has-post-thumbnail"],"acf":[],"yoast_head":"\nTests mol\u00e9culaires - Lymphoma Canada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tests mol\u00e9culaires - Lymphoma Canada\" \/>\n<meta property=\"og:description\" content=\"  Le m\u00e9decin peut faire passer d\u2019autres examens pour d\u00e9couvrir quelles sont les anomalies chromosomiques et les modifications g\u00e9n\u00e9tiques pr\u00e9sentes dans les cellules de la LLC. Les r\u00e9sultats de ces...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/\" \/>\n<meta property=\"og:site_name\" content=\"Lymphoma Canada\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/LymphomaCanada\" \/>\n<meta property=\"article:modified_time\" content=\"2020-02-06T03:05:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.lymphoma.ca\/wp-content\/uploads\/2019\/09\/molecular_testing_page_callout_fr.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"341\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@lymphomacanada\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/\",\"url\":\"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/\",\"name\":\"Tests mol\u00e9culaires - Lymphoma Canada\",\"isPartOf\":{\"@id\":\"https:\/\/www.lymphoma.ca\/fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.lymphoma.ca\/wp-content\/uploads\/2019\/09\/molecular_testing_page_callout_fr.jpg\",\"datePublished\":\"2019-09-11T20:21:55+00:00\",\"dateModified\":\"2020-02-06T03:05:38+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.lymphoma.ca\/fr\/le-lymphome\/la-llc\/le-diagnostic\/tests-de-laboratoire\/tests-moleculaires\/#primaryimage\",\"url\":\"https:\/\/www.lymphoma.ca\/wp-content\/uploads\/2019\/09\/molecular_testing_page_callout_fr.jpg\",\"contentUrl\":\"https:\/\/www.lymphoma.ca\/wp-content\/uploads\/2019\/09\/molecular_testing_page_callout_fr.jpg\",\"width\":1024,\"height\":341,\"caption\":\"\u00caTES-VOUS ATTEINT DE LLC? 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