A recent discovery revealed that a gene called KMT2D does not directly drive uncontrolled cell growth, but instead controls the activity of hundreds of other genes through a process called epigenetic regulations.
The KMT2D gene is mutated in a least half of all follicular lymphoma tumors.
Follicular lymphoma is a subtype of non-Hodgkin lymphoma and while effective treatments exist, approximately 20 per cent of patients respond poorly or not at all to current therapies.
Understanding the molecular cause is an important step toward new and better therapies for this common, incurable form of non-Hodgkin lymphoma.
Researchers Discover How Gene Mutation Leads to Follicular Lymphoma: September 23, 2015 - https://www.mskcc.org/blog/researchers-discover-how-gene-mutation-leads-...